Oral Delivery

Oral delivery continues to be the favoured route of drug administration for patients and clinicians.

Effective oral delivery requires a compound to overcome three major barriers in sufficient amount to yield a therapeutic effect: the digestive barrier, the mucus barrier and the epithelial barrier. Each of these pose a challenge to drug delivery.

Available in vitro models can have limited physiological relevance: ignoring the role of digestive enzymes and components of bile in the digestive milieu; overlooking mucus permeation as a vital step in absorption; and looking at dissolution, permeation and absorption in isolated assays rather than as part of an integrated system.