Gastrointestinal Models

Test  Phase Modeled  Description
Upper GI Digestion Model Digestive Phase Examine how API/Formulation affects or is affected by chemical and enzymatic processes of digestion in the upper digestive tract model
Mucus Permeation Model Mucus Permeation Phase Examine how API/Formulation permeates through mucus, and how mucus function is affected. This can be done in different conditions: Simple buffer system: Simulated intestinal fluids (without enzymes and bile); or Model digestive fluids (complete with enzymes and bile)
Cell Culture Systems Epithelial Absorption Phase Established models of gastrointestinal epithelia
Integrated Digestion and Mucus Permeation Model Digestive Phase, Mucus Permeation Phase Investigate cumulative effects of digestion and mucus permeation.  Examine how API/Formulation affects or is affected by digestion, and how this goes on to effect mucus permeation and mucus function
Integrated Mucus Permeation and Cell Culture Models Mucus Permeation Phase, Epithelial Absorption Phase Investigate API/Formulation delivery across integrated model of mucus and epithelial barrier.
Integrated Upper GI Digestion, Mucus Permeation and Epithelial Absorption Model Digestive Phase, Mucus Permeation Phase, Epithelial Absorption Phase Investigate API/Formulation delivery through entire system with integrated model of digestion, mucus permeation and epithelial barrier.