Test | Phase Modeled | Description |
Upper GI Digestion Model | Digestive Phase | Examine how API/Formulation affects or is affected by chemical and enzymatic processes of digestion in the upper digestive tract model |
Mucus Permeation Model | Mucus Permeation Phase | Examine how API/Formulation permeates through mucus, and how mucus function is affected. This can be done in different conditions: Simple buffer system: Simulated intestinal fluids (without enzymes and bile); or Model digestive fluids (complete with enzymes and bile) |
Cell Culture Systems | Epithelial Absorption Phase | Established models of gastrointestinal epithelia |
Integrated Digestion and Mucus Permeation Model | Digestive Phase, Mucus Permeation Phase | Investigate cumulative effects of digestion and mucus permeation. Examine how API/Formulation affects or is affected by digestion, and how this goes on to effect mucus permeation and mucus function |
Integrated Mucus Permeation and Cell Culture Models | Mucus Permeation Phase, Epithelial Absorption Phase | Investigate API/Formulation delivery across integrated model of mucus and epithelial barrier. |
Integrated Upper GI Digestion, Mucus Permeation and Epithelial Absorption Model | Digestive Phase, Mucus Permeation Phase, Epithelial Absorption Phase | Investigate API/Formulation delivery through entire system with integrated model of digestion, mucus permeation and epithelial barrier.
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