Here at Aelius, we have developed a novel method for rebuilding physiologically relevant mucus gels. This means we can combine a mucus layer with cell culture systems to model the mucosal surfaces of the body.

Using this technique we have developed an integrated in vitro model of gastrointestinal digestion and absorption for testing oral drug delivery. This is the first system of its kind capable of integrating a cell culture system with a physiologically accurate mucus layer and whole digestive secretions including bile and digestive enzymes.

Our systems can be used as a pre-clinical screening and development tool for oral drug delivery, to test uptake and refine formulations. We aim to make the development of oral pharmaceuticals cheaper, quicker and more effective.