Publications - Aelius Biotech

Our Publications

Advancing gastrointestinal science through peer-reviewed research and innovative discoveries

Recent Publications

BITE Human Trials

A Pilot Pre and Post 4 Week Intervention Evaluating the Effect of a Proprietary, Powdered, Plant Based Food on Micronutrient Status, Dietary Intake, and Markers of Health in a Healthy Adult Population

Wilcox MD, Chater PI, Stanforth KJ, Williams R, Brownlee IA, Pearson JP.

Frontiers in Nutrition (2022)

Acceptability of alginate enriched bread and its effect on fat digestion in humans

Houghton D, et al.

Food Hydrocolloids (2019)

Mucus Physiology and Drug Delivery

The MUC2 Gene Product: Polymerisation and Post-Secretory Organisation—Current Models

Stanforth KJ, Zakhour MI, Chater PI, Wilcox MD, Adamson B, Robson NA, Pearson JP.

Polymers (2024)

In vitro modelling of the mucosa of the oesophagus and upper digestive tract

Stanforth K, Chater P, Brownlee I, Wilcox M, Ward C, Pearson J.

Annals of Esophagus (2021)

Efficacy and safety concerns over the use of mucus modulating agents for drug delivery using nanoscale systems

Chater PI, Wilcox MD, Pearson JP.

Advanced Drug Delivery Reviews (2017)

ζ potential changing nanoparticles as cystic fibrosis transmembrane conductance regulator gene delivery system: an in vitro evaluation

Prüfert F, Bonengel S, Köllner S, Griesser J, Wilcox MD, Chater PI, Pearson JP, Bernkop-Schnürch A.

Nanomedicine (2017)

The properties of the mucus barrier, a unique gel–how can nanoparticles cross it?

Pearson JP, Chater PI, Wilcox MD.

Therapeutic Delivery (2016)

The effect of nanoparticle permeation on the bulk rheological properties of mucus from the small intestine

Wilcox MD, Van Rooij LK, Chater PI, Pereira de Sousa I, Pearson JP.

European Journal of Pharmaceutics and Biopharmaceutics (2015)

Digestion & The Upper GI Tract

The effect of seaweed enriched bread on carbohydrate digestion and the release of glucose from food

Wilcox MD, Cherry P, Chater P, Yang X, Zulali M, Okello EJ, Seal CJ, Pearson JP.

Journal of Functional Foods (2021)

The rheological properties of an alginate satiety formulation in a physiologically relevant human model gut system

Wilcox MD, Chater PI, Stanforth KJ, Woodcock AD, Dettmar PW, Pearson JP.

Annals of Esophagus (2021)

Encapsulation of stevia rebaudiana Bertoni aqueous crude extracts by ionic gelation--Effects of alginate blends and gelling solutions on the polyphenolic profile

Arriola NDA, Chater PI, Wilcox M, Lucini L, Rocchetti G, Dalmina M, Amboni RDDMC.

Food Chemistry (2019)

Starch digestion in the upper gastrointestinal tract of humans

Brownlee IA, Gill S, Wilcox MW, Pearson JP, Chater PI.

Starch‐Stärke

Dietary fibre and weight loss: Where are we now?

Brownlee I, Chater P, Pearson J, Wilcox M.

Food Hydrocolloids (2016)

The impact of dietary fibres on the physiological processes governing small intestinal digestive processes

Chater P, Wilcox M, Pearson J, Brownlee I.

Bioactive Carbohydrates and Dietary Fibre (2015)

Inhibitory activity of extracts of Hebridean brown seaweeds on lipase activity

Chater P, Wilcox M, Cherry P, Herford A, Mustar S, Wheater H, Brownlee I, Seal C, Pearson J.

Journal of Applied Phycology (2016)

The role of seaweed bioactives in the control of digestion: Implications for obesity treatments

Chater P, Wilcox M, Houghton D, Pearson J.

Food & Function (2015)

Alginate as a protease inhibitor in vitro and in a model gut system; selective inhibition of pepsin but not trypsin

Chater P, Wilcox M, Brownlee I, Pearson J.

Carbohydrate Polymers (2015)

A synthetic model gut system to study macronutrient digestion in vitro

Chater P, Wilcox M, Brownlee I, Pearson J.

Proceedings of The Nutrition Society (2015)

Biological activity of alginate and its effect on pancreatic lipase inhibition as a potential treatment for obesity

Houghton D, Wilcox M, Chater P, Brownlee I, Seal C, Pearson J.

Food Hydrocolloids (2015)

Method for quantifying alginate and determining release from a food vehicle in gastrointestinal digesta

Houghton D, Wilcox M, Brownlee I, Chater P, Seal C, Pearson J.

Food Chemistry (2014)

Pepsin, Reflux & Airways

Pepsin properties, structure, and its accurate measurement: a narrative review

Stanforth KJ, Wilcox MD, Chater PI, Brownlee IA, Zakhour MI, Banecki KMRM, et al.

Annals of Esophagus (2021)

Pathological Processes

Pearson JP, Aldhahrani A, Chater PI, Wilcox MD.

In: Reflux Aspiration and Lung Disease, Springer (2018)

Bile acids in laryngopharyngeal refluxate: Will they enhance or attenuate the action of pepsin?

Ali M, Parikh S, Chater P, Pearson J.

The Laryngoscope (2013)

Microbiome

Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown

Crouch L, Liberato M, Urbanowicz P, Basle A, Lamb C, Stewart C, Cooke K, Doona M, Needham S, Brady R, Berrington J, Madunic K, Wuhrer M, Chater P, Pearson J, Glowacki R, Martens E, Zhang F, Linhardt R, Spencer D, Bolam D.

Nature Communications (2020)

The impact of dietary fibres on the physiological processes of the large intestine

Gill S, et al.

Bioactive Carbohydrates and Dietary Fibre (2018)

A narrative review of the potential role of microaspiration and a dysregulated aerodigestive microbiome in lung disease

Althuwaybi A, Alamer A, McDonnell MJ, Brennan M, Rutherford RM, Wilcox M, Chater P, Pearson J, Ward C.

Annals of Esophagus (2021)

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